Oxidative Stress Contributes to Status Epilepticus Associated Mortality

Mortality due to SUDEP and status epilepticus.

Mortality in patients with epilepsy (PWE) is increased compared to the general population. For this reason the National Programme of Epilepsy Care, which was established under the Health Service Executive's National Director for Clinical Strategy and Programmes, identified a reduction in mortality from epilepsy as a key quality metric to monitor the success of the programme. The increased morta...

Status Epilepticus in Immature Rats Is Associated with Oxidative Stress and Mitochondrial Dysfunction

Epilepsy is a neurologic disorder, particularly frequent in infants and children where it can lead to serious consequences later in life. Oxidative stress and mitochondrial dysfunction are implicated in the pathogenesis of many neurological disorders including epilepsy in adults. However, their role in immature epileptic brain is unclear since there have been two contrary opinions: oxidative st...

Short-term mortality and prognostic factors related to status epilepticus.

OBJECTIVE Status epilepticus (SE) is associated with significant morbidity and mortality, and there is some controversy concerning predictive indicators of outcome. Our main goal was to determine mortality and to identify factors associated with SE prognosis. METHOD This prospective study in a tertiary-care university hospital, included 105 patients with epileptic seizures lasting more than 3...

StEPing "EP2" to Prevent Status Epilepticus-Induced Mortality and Inflammation.

Oxidative stress mediates hippocampal neuron death in rats after lithium–pilocarpine-induced status epilepticus

Oxidative stress, which is defined as the over-production of free radicals, can dramatically alter neuronal function and has been linked to status epilepticus (SE). The pathological process and underlying mechanisms involved in the oxidative stress during SE are still not fully clear. In the current study, SE was induced in rats by lithium-pilocarpine administration. Our data show that hippocam...